Double-stranded RNA (dsRNA) is a form of ribonucleic acid composed of two complementary, antiparallel strands paired together, in contrast to the single-stranded RNA found in most cellular messenger and transfer RNAs. It occurs naturally as the genome or replication intermediate of certain viruses and as short regul…
Double-stranded RNA (dsRNA) is a form of ribonucleic acid composed of two complementary, antiparallel strands paired together, in contrast to the single-stranded RNA found in most cellular messenger and transfer RNAs. It occurs naturally as the genome or replication intermediate of certain viruses and as short regulatory molecules within cells, and it plays central roles in controlling gene expression. Long and short dsRNAs trigger RNA interference, a conserved process in which the dsRNA is processed into small fragments that guide the silencing of complementary genes, enabling defense against viruses and the fine-tuning of gene activity. The recognition of dsRNA by cellular sensors also activates innate immune responses. These properties make dsRNA important both as a biological regulator and as a research and therapeutic tool. As a journal of DNA And RNA Research, this title's scope covers nucleic acid structure, function, and technology, including the synthesis and analysis of RNA and DNA molecules and their roles in gene regulation. The articles associated with this page address related nucleic acid topics rather than double-stranded RNA specifically, so this entry provides an encyclopedic definition within the journal's nucleic acid research scope. It serves as a reference overview of double-stranded RNA and its biological significance.
10 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 10 articles above have been cited 16 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Double Stranded Rna, linking to each citing work.