DNA damage repair refers to the collection of cellular processes that detect and correct damage to DNA, preserving the integrity of the genetic material. DNA is continually exposed to damaging influences, including ultraviolet and ionizing radiation, reactive oxygen species, chemical mutagens, and errors that arise …
DNA damage repair refers to the collection of cellular processes that detect and correct damage to DNA, preserving the integrity of the genetic material. DNA is continually exposed to damaging influences, including ultraviolet and ionizing radiation, reactive oxygen species, chemical mutagens, and errors that arise during DNA replication. If left uncorrected, this damage can produce mutations, chromosomal abnormalities, and loss of normal cell function. Cells possess multiple repair pathways tailored to different kinds of lesions, such as base excision repair, nucleotide excision repair, mismatch repair, and pathways that mend single- and double-strand breaks. These systems recognize the damage, remove or correct the affected nucleotides, and restore the original sequence, often using the complementary strand or a sister chromatid as a template. Effective DNA damage repair is essential for cell survival, accurate inheritance, and the prevention of disease, and defects in repair pathways are linked to cancer, premature aging, and genetic disorders. Research in this area also informs understanding of how chemotherapy and radiation affect cells, since these treatments act in part by overwhelming repair capacity. As part of DNA And RNA Research, this open-access page brings together peer-reviewed studies relevant to genome stability, DNA damage and oxidative stress, and the molecular mechanisms that maintain the integrity of the genome.
9 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 9 articles above have been cited 33 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Dna Damage Repair, linking to each citing work.