DNA damage refers to chemical and structural alterations to the genome, including base modifications, single- and double-strand breaks, abasic sites, crosslinks and oxidised lesions such as 8-oxo-7,8-dihydro-2'-deoxyguanosine. Damage arises from endogenous sources such as reactive oxygen species and replication erro…
DNA damage refers to chemical and structural alterations to the genome, including base modifications, single- and double-strand breaks, abasic sites, crosslinks and oxidised lesions such as 8-oxo-7,8-dihydro-2'-deoxyguanosine. Damage arises from endogenous sources such as reactive oxygen species and replication errors and from exogenous agents including ionising and ultraviolet radiation, environmental chemicals and radiofrequency exposure. If unrepaired, lesions cause mutation, genomic instability, cellular senescence or death, and contribute to ageing and carcinogenesis. The journal publishes peer-reviewed research on these processes, including studies of the redox potential of phytochemicals and their impact on DNA, oxidative telomere attrition and nutritional antioxidants, dietary interventions and measured DNA damage, analytical quantification of oxidative guanine lesions, and the structural and functional consequences of disease-associated variants such as those in BRCA1. The measurement of oxidative DNA adducts and the modulation of damage by diet, antioxidants and toxicants are recurring themes. Because the burden of unrepaired lesions links environmental exposure to mutation and disease, DNA damage is a central concept in genome maintenance, oxidative-stress biology, cancer research, toxicology and the molecular biology of ageing.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 53 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Dna Damage, linking to each citing work.