Research Topic · Peer-Reviewed

Necrosis

Necrosis is a form of cell death resulting from acute injury, in which cells lose membrane integrity, swell, and rupture, releasing intracellular contents that provoke inflammation and surrounding tissue damage. Unlike the regulated, non-inflammatory process of apoptosis, classical necrosis is typically uncontrolled…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 70× across the literature 🔖 ISSN 2997-1977 🗓 Reviewed October 2026

Overview

Necrosis is a form of cell death resulting from acute injury, in which cells lose membrane integrity, swell, and rupture, releasing intracellular contents that provoke inflammation and surrounding tissue damage. Unlike the regulated, non-inflammatory process of apoptosis, classical necrosis is typically uncontrolled and follows ischemia, infection, toxic exposure, or physical trauma, though regulated necrotic pathways are also recognized. It is implicated across infectious, neoplastic, ischemic, and degenerative disease and contributes to organ dysfunction through tissue destruction and the release of damage-associated molecules. The peer-reviewed research collected here reflects these themes through reports of lymphoma with extensive necrosis, quercetin attenuation of manganese neurotoxicity involving tumour necrosis factor alpha regulation, and reversible and irreversible cerebral necrosis following cardiorespiratory arrest. Related contributions examine apoptosis and oxidative stress in stored platelets and in testicular tissue under lipopolysaccharide challenge, computed-tomography severity indices and biochemical markers in acute pancreatitis, and proinflammatory cytokine expression in tissue homogenates. Further work addresses neoplastic tissue damage, adrenal structural change under chemical exposure, and oxidative end products in hemodialysis. Methodologically, the literature draws on histopathology, biochemical and cytokine analysis, animal models, and clinical case study, illustrating how necrosis connects cellular injury, inflammation, and tissue destruction across infectious, toxic, ischemic, and neoplastic conditions, and how its assessment informs understanding of disease severity and progression.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 70 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Necrosis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Diseases (ISSN 2997-1977).

Journal editorial board
Charles Edward Rupprecht · United States Dr. Md. Rabiul Islam · Bangladesh Madalena Barroso · Germany

This page summarises published research for orientation; it is not medical or professional advice.