2017
A Model for Identifying Actionable Findings on Computed Tomography in Crohn’s Disease Patients in the Emergency Department
Kian KeyashianCorresponding author
Overview
Chief cells are specialized epithelial cells located in the gastric glands of the stomach that secrete pepsinogen, the inactive precursor of the digestive enzyme pepsin. These cells play a fundamental role in protein digestion within the gastrointestinal tract. In the context of digestive disorders, chief cells and their secretory products are relevant to understanding normal gastric physiology and pathological conditions affecting the stomach and broader digestive system. Research published in Digestive Disorders And Diagnosis has examined chief cells within the framework of inflammatory bowel disease evaluation, specifically in developing clinical models for identifying significant findings in Crohn's disease patients presenting to emergency departments. This work reflects the broader clinical importance of understanding gastric and intestinal cellular function when assessing acute presentations of chronic digestive disorders. The study of chief cells matters because alterations in gastric secretion and mucosal integrity can influence disease progression, nutritional status, and clinical decision-making in patients with complex digestive pathology. Understanding the role of these cells contributes to comprehensive assessment strategies for patients with inflammatory and structural gastrointestinal conditions requiring urgent medical attention.
Research published in this journal
1 peer-reviewed article, ranked by relevance. Each links to its DOI.
How this research is being cited
The 1 article above has been cited 2 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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2022 · Journal of Clinical Gastroenterology
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2021 · Journal of Clinical Gastroenterology
A sample of recent works citing this journal's research on Chief Cells, linking to each citing work.