Colorectal cancer is a malignancy that arises in the colon (large intestine) or rectum, most often developing from precancerous polyps in the bowel lining. It is among the most common cancers worldwide and a leading cause of cancer-related death, though early detection through screening substantially improves outcom…
Colorectal cancer is a malignancy that arises in the colon (large intestine) or rectum, most often developing from precancerous polyps in the bowel lining. It is among the most common cancers worldwide and a leading cause of cancer-related death, though early detection through screening substantially improves outcomes. Risk is shaped by age, genetic and hereditary factors, inflammatory bowel conditions, and lifestyle and dietary influences, and the disease progresses through recognizable molecular and histological pathways of carcinogenesis. Screening modalities such as the fecal immunochemical test (FIT) and colonoscopy aim to detect cancer and its precursors early, while treatment involves surgical resection, chemotherapy, and other modalities according to stage. Research published under this topic includes compliance with company-based FIT screening, the design of population-based screening programs, and the role of serrated lesions and proximal-colon features in interval cancers. Further work addresses chemoprevention with nonsteroidal anti-inflammatory drugs, molecular mechanisms such as RNF43 regulation, prostate apoptosis response protein-4 in metastasis, and resistance to butyrate-induced apoptosis, alongside perioperative cardiac risk in cancer resection, dietary and lifestyle intervention, and the mental-health and psychological dimensions of screening and survivorship, reflecting the broad clinical, molecular, and public-health scope of the disease.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 31 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Colorectal Cancer, linking to each citing work.