Theo van Laar
Delft University of Technology · Delft University of Technology
Editorial leadership for Journal of Chromosomes
Research interests
- Single Molecule Eucaryotic Replication
Biography
Theo van Laar is a researcher at Delft University of Technology whose work focuses on single-molecule biophysics and the molecular mechanisms of DNA replication and protein-DNA interactions. His most-cited publication, "DNA replication origins retain mobile licensing proteins" (2021), has been cited 39 times and represents a significant contribution to understanding replication licensing dynamics. Van Laar has developed and applied advanced biophysical techniques, including high-throughput magnetic tweezers for probing DNA-protein interactions with high force resolution, and single-molecule fluorescence microscopy to investigate protein dynamics at the single-cell level. His research encompasses the study of RNA-dependent RNA polymerase activity, replication fork barriers, and methodological innovations such as covalent DNA anchoring strategies to enhance the stability of single-molecule experiments.
Selected publications
- DNA replication origins retain mobile licensing proteins 2021 cited 39×
- Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation 2023 cited 17×
- A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint 2023 cited 10×
- Clonal autoantibodies identify microbial antigen as trigger of autoreactive B cells in systemic sclerosis Recent 2026
Ranked by citation impact (Crossref) where available, newest otherwise · verified via ORCID.
Considering JC for your work?
This journal is guided by Theo van Laar (Delft University of Technology) and a peer-review board of practising researchers. Open access, author-retained copyright (CC BY), and a clear editorial process.