Carcinogenesis is the multistep process by which normal cells acquire the genetic and epigenetic alterations that transform them into malignant cells, classically described through the stages of initiation, promotion, and progression. Driver mutations in oncogenes and tumor-suppressor genes, together with epigenetic…
Carcinogenesis is the multistep process by which normal cells acquire the genetic and epigenetic alterations that transform them into malignant cells, classically described through the stages of initiation, promotion, and progression. Driver mutations in oncogenes and tumor-suppressor genes, together with epigenetic reprogramming and genomic instability, dysregulate proliferation, differentiation, DNA repair, and apoptosis, allowing clonal expansion and eventual invasion and metastasis. Causes are heterogeneous and include chemical, physical, and viral carcinogens as well as inherited susceptibility and lifestyle exposures, and elucidating these mechanisms underpins prevention, screening, and targeted treatment. Research relevant to this area examines the mutational landscape of TP53 in oral cancer, the role of human papillomavirus in virus-induced carcinogenesis, serrated and other pathways of colorectal carcinogenesis and chemotherapeutic responsiveness, epigenetic and long non-coding RNA biomarkers in head-and-neck cancer, microRNA expression in melanoma progression, and chemically induced colon cancer in experimental models. The journal publishes peer-reviewed work in Cancer Genetics And Biomarkers addressing the molecular, viral, epigenetic, and environmental drivers of malignant transformation, linking studies of tumor-suppressor mutation, oncogenic infection, and tissue-specific carcinogenic pathways to the diagnosis, prevention, and treatment of cancer across multiple organ sites.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 34 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Carcinogenesis, linking to each citing work.