Cancer gene therapy is a therapeutic strategy that introduces, edits, silences, or replaces genetic material within cells to counteract the molecular drivers of malignancy. Its rationale rests on the genetic basis of cancer, in which somatic and germline alterations in tumour-suppressor genes and oncogenes initiate …
Cancer gene therapy is a therapeutic strategy that introduces, edits, silences, or replaces genetic material within cells to counteract the molecular drivers of malignancy. Its rationale rests on the genetic basis of cancer, in which somatic and germline alterations in tumour-suppressor genes and oncogenes initiate and sustain tumour growth; characterising such changes, including BRCA1 variants of uncertain significance and the mutational landscape of TP53, defines the targets that gene-based interventions aim to correct. Strategies include restoring function to inactivated tumour suppressors, inhibiting oncogenic signalling, and modulating gene-expression programmes implicated in proliferation and metastasis. Related molecular work, such as the analysis of interferon-gamma signalling mutations in uterine leiomyosarcoma and the study of insulin-receptor-substrate expression in breast cancer, illustrates the pathways that therapy seeks to influence. Understanding the molecular and cell-biological events that initiate sporadic, non-hereditary solid cancers further informs which lesions are amenable to genetic correction. Immunogenomic and immunoassay approaches connect gene therapy to immune-based monitoring, and microRNA expression profiling offers both targets and biomarkers of response. Viral associations, as with Epstein-Barr virus in gastric carcinoma, broaden the contexts in which gene-directed approaches are considered. By acting on the genetic and regulatory machinery of tumour cells, cancer gene therapy aims to suppress malignant behaviour and complement conventional treatment.
8 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 8 articles above have been cited 28 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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