Cancer gene expression refers to the patterns by which genes are transcribed into RNA and ultimately translated into protein within tumor cells, and to the ways these patterns are reprogrammed during malignant transformation. In cancer, the normal regulation of expression is disrupted, so that oncogenes, growth and …
Cancer gene expression refers to the patterns by which genes are transcribed into RNA and ultimately translated into protein within tumor cells, and to the ways these patterns are reprogrammed during malignant transformation. In cancer, the normal regulation of expression is disrupted, so that oncogenes, growth and survival pathways, and resistance programs become aberrantly active while protective programs are silenced. Studying these transcriptional profiles reveals which genes drive initiation and progression and which mark distinct tumor states. Work in this area examines the regulation of expression at multiple levels, including transcriptional control of stem-cell and signaling genes, regulatory loops involving microRNAs that fine-tune target transcripts, and pathway-specific regulation such as that affecting colorectal cancer signaling. Investigators use gene expression analysis to dissect mechanisms underlying apoptosis resistance, to characterize how somatic mutations alter downstream signaling, and to relate expression-based recurrence scores to clinical features. MicroRNA expression in tissue and plasma is studied both as a regulator of gene activity and as a quantifiable readout of tumor biology, including correlations with progression and survival. Expression profiling thus links molecular events to phenotype, supporting tumor classification, the identification of therapeutic targets, and the development of nucleic-acid-based diagnostic approaches grounded in the activity of cancer-associated genes.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 40 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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