Protein synthesis is the biosynthetic process by which cells assemble polypeptide chains from amino acids according to the genetic code, comprising transcription of DNA into messenger RNA and translation of that template by ribosomes with the assistance of transfer RNAs, aminoacyl-tRNA synthetases, and an array of i…
Protein synthesis is the biosynthetic process by which cells assemble polypeptide chains from amino acids according to the genetic code, comprising transcription of DNA into messenger RNA and translation of that template by ribosomes with the assistance of transfer RNAs, aminoacyl-tRNA synthetases, and an array of initiation, elongation, and termination factors. Each amino acid is delivered by its cognate charged transfer RNA and joined through peptide-bond formation catalysed by the ribosomal RNA, after which the nascent chain folds and may undergo post-translational modification to become functional. The fidelity and rate of synthesis are regulated at multiple levels and are essential for cellular growth, tissue repair, and the maintenance of the proteome. Research indexed under this topic addresses amino acid metabolism and the incorporation of residues such as tryptophan, the influence of nutritional and dietary factors including high-protein and high-fat regimes on muscle and tissue protein accretion, signature proteins distinguishing major domains of life, and hormonal and oxidative-stress modulation of protein-dependent processes. Analytical methods include mass spectrometry, isotopic abundance measurement, and molecular modelling. The peer-reviewed work collected here links the molecular machinery of translation to physiology, biochemistry, and applied biomedical questions, reflecting protein synthesis as the central conduit through which genetic information becomes biological function.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 73 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Protein Synthesis, linking to each citing work.