Research Topic · Peer-Reviewed

Protein Engineering

Protein engineering is the science of designing and constructing proteins with new or improved functions by altering their amino acid sequences and, consequently, their three-dimensional structures. It includes rational design, which uses knowledge of a protein's structure and function to make targeted changes, and …

Curated from this journal's research 📚 3 peer-reviewed articles cited Cited 59× across the literature 🔖 ISSN 2374-9431 🗓 Reviewed July 2026

Overview

Protein engineering is the science of designing and constructing proteins with new or improved functions by altering their amino acid sequences and, consequently, their three-dimensional structures. It includes rational design, which uses knowledge of a protein's structure and function to make targeted changes, and directed evolution, which mimics natural selection by generating many variants and selecting those with desired properties. Through these approaches, researchers can modify existing proteins, such as enzymes, to enhance stability, activity, or specificity, or create novel proteins for applications in medicine, diagnostics, biosensors, and industrial processes. Protein engineering relies heavily on computational and bioinformatic tools to model protein structures, predict the effects of mutations, and guide design, linking it closely to the analysis of biological sequence and structural data. Within the broader scope of bioinformatics and related biomedical research, including the study of enzymes and metabolic proteins, computational methods support the understanding and manipulation of protein behavior. By enabling the deliberate tailoring of proteins, protein engineering contributes to therapeutic development, biotechnology, and the study of how protein structure determines function. This page presents encyclopedic background on protein engineering, its rational and evolutionary strategies, and its connection to computational and bioinformatic analysis of proteins.

Research published in this journal

3 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 3 articles above have been cited 59 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Protein Engineering, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Bioinformatics And Diabetes (ISSN 2374-9431).

Journal editorial board
Wei Wang · United States Chol Hee Jung · Australia Emile Chimusa · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.