Research Topic · Peer-Reviewed

Experimental Diabetes Mellitus

Experimental diabetes mellitus is diabetes reproduced in laboratory animal models so that its mechanisms, complications, and treatments can be studied under controlled conditions. Such models are commonly generated with chemical agents like streptozotocin, which selectively destroy insulin-producing pancreatic beta …

Curated from this journal's research 📚 10 peer-reviewed articles cited Cited 86× across the literature 🔖 ISSN 2374-9431 🗓 Reviewed July 2026

Overview

Experimental diabetes mellitus is diabetes reproduced in laboratory animal models so that its mechanisms, complications, and treatments can be studied under controlled conditions. Such models are commonly generated with chemical agents like streptozotocin, which selectively destroy insulin-producing pancreatic beta cells and induce the hyperglycemia characteristic of the disease, allowing investigators to examine pathophysiology that cannot be probed directly in patients. Through these models, researchers study how diabetes disrupts hematological and biochemical parameters, reproductive function, kidney and retinal tissue, and cardiovascular regulation, and how genetic, hormonal, and metabolic factors govern disease onset and progression. Experimental diabetes is central to drug discovery and evaluation, providing a reproducible system in which conventional hypoglycemic medicines and plant-derived or complementary agents can be tested for effects on glucose control, oxidative stress, and tissue protection before clinical application. The approach complements clinical and epidemiological investigation of conditions such as gestational and type 2 diabetes and connects with bioinformatic and metabolomic analyses that characterize the molecular signatures of the disease. By offering a controlled platform for mechanistic study and therapeutic testing, experimental diabetes mellitus remains a foundational tool for advancing knowledge of diabetes biology and for developing safer, more effective interventions.

Research published in this journal

10 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2013

Kynurenines and Vitamin B6: Link Between Diabetes and Depression.

Oxenkrug GregoryCorresponding author
Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine and Tufts Medical Center, Boston MA, USA.
Bioinformatics And Diabetes Cited by 31 doi:10.14302/issn.2374-9431.jbd-13-218
2014

Bioinformatics of Metabolomics in Diabetes Mellitus Type 2

Ahmad Sliem HamdyCorresponding author
Biochemistry and internal Medicine*, Basic oral and medical sciences, College of dentistry, Qassim University, Saudi Arabia
Bioinformatics And Diabetes Cited by 2 doi:10.14302/issn.2374-9431.jbd-13-212

How this research is being cited

The 10 articles above have been cited 86 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Experimental Diabetes Mellitus, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Bioinformatics And Diabetes (ISSN 2374-9431).

Journal editorial board
Wei Wang · United States Chol Hee Jung · Australia Emile Chimusa · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.