Research Topic · Peer-Reviewed

Diabetic Kidney Disease

Diabetic kidney disease, also called diabetic nephropathy, is a progressive complication of type 1 and type 2 diabetes in which chronic hyperglycemia damages the kidneys' filtering structures. It is among the most common microvascular complications of diabetes and a leading cause of chronic kidney disease and end-st…

Curated from this journal's research 📚 10 peer-reviewed articles cited Cited 165× across the literature 🔖 ISSN 2374-9431 🗓 Reviewed July 2026

Overview

Diabetic kidney disease, also called diabetic nephropathy, is a progressive complication of type 1 and type 2 diabetes in which chronic hyperglycemia damages the kidneys' filtering structures. It is among the most common microvascular complications of diabetes and a leading cause of chronic kidney disease and end-stage renal failure worldwide. The disease develops as sustained high blood glucose, often compounded by hypertension, injures the glomeruli, leading to thickening of the basement membrane, mesangial expansion, and increased permeability that allows protein, initially albumin, to leak into the urine. Clinically it is marked by albuminuria, declining glomerular filtration rate, and rising blood pressure, with oxidative stress and inflammatory mediators contributing to ongoing damage. Research in this area uses bioinformatic resources to identify genes, pathways, and biomarkers relevant to nephropathy, and investigates relationships between diabetes, metabolic markers, advanced oxidation products, and inflammation in patients, including those on dialysis. Management focuses on glycemic and blood-pressure control, reduction of proteinuria, and protection of remaining kidney function, while complementary and pharmacological agents are studied for renoprotective effects. Understanding diabetic kidney disease integrates metabolic, vascular, genetic, and inflammatory mechanisms to enable earlier detection and to slow progression toward kidney failure.

Research published in this journal

10 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2013

Bioinformatic Resources for Diabetic Nephropathy

Jayne McKnight AmyCorresponding author
Nephrology Research, Centre for Public Health, Queen’s University of Belfast
Exact topic Bioinformatics And Diabetes Cited by 4 doi:10.14302/issn.2374-9431.jbd-13-226
2013

Kynurenines and Vitamin B6: Link Between Diabetes and Depression.

Oxenkrug GregoryCorresponding author
Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine and Tufts Medical Center, Boston MA, USA.
Bioinformatics And Diabetes Cited by 31 doi:10.14302/issn.2374-9431.jbd-13-218
2014

Bioinformatics of Metabolomics in Diabetes Mellitus Type 2

Ahmad Sliem HamdyCorresponding author
Biochemistry and internal Medicine*, Basic oral and medical sciences, College of dentistry, Qassim University, Saudi Arabia
Bioinformatics And Diabetes Cited by 2 doi:10.14302/issn.2374-9431.jbd-13-212

How this research is being cited

The 10 articles above have been cited 165 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Diabetic Kidney Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Bioinformatics And Diabetes (ISSN 2374-9431).

Journal editorial board
Wei Wang · United States Chol Hee Jung · Australia Emile Chimusa · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.