Research Topic · Peer-Reviewed

Diabetes Mellitus, Experimental

Experimental diabetes mellitus refers to diabetes induced or studied in laboratory animal models to investigate the disease's causes, mechanisms, and treatments under controlled conditions. Such models, often produced by chemical agents like streptozotocin that destroy insulin-producing pancreatic beta cells, reprod…

Curated from this journal's research 📚 10 peer-reviewed articles cited Cited 86× across the literature 🔖 ISSN 2374-9431 🗓 Reviewed July 2026

Overview

Experimental diabetes mellitus refers to diabetes induced or studied in laboratory animal models to investigate the disease's causes, mechanisms, and treatments under controlled conditions. Such models, often produced by chemical agents like streptozotocin that destroy insulin-producing pancreatic beta cells, reproduce the hyperglycemia and metabolic disturbances of human diabetes and allow researchers to examine pathophysiology that cannot be studied directly in patients. Using these models, investigators explore how the disease affects hematological and biochemical parameters, the reproductive system, the kidneys, the retina, and cardiovascular function, and how genetic, hormonal, and metabolic factors contribute to onset and progression. Experimental diabetes is central to evaluating candidate therapies, including conventional hypoglycemic drugs and plant-derived or complementary agents, by measuring their effects on glucose control, oxidative stress, and tissue damage. The approach complements clinical and epidemiological study of conditions such as gestational and type 2 diabetes, and connects with bioinformatic and metabolomic analyses that map the molecular changes underlying the disease. By providing a reproducible system in which interventions can be tested for efficacy and safety before clinical use, experimental diabetes mellitus models remain a foundational tool for advancing understanding of diabetes biology and developing new treatments.

Research published in this journal

10 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2013

Kynurenines and Vitamin B6: Link Between Diabetes and Depression.

Oxenkrug GregoryCorresponding author
Psychiatry and Inflammation Program, Department of Psychiatry, Tufts University School of Medicine and Tufts Medical Center, Boston MA, USA.
Bioinformatics And Diabetes Cited by 31 doi:10.14302/issn.2374-9431.jbd-13-218
2014

Bioinformatics of Metabolomics in Diabetes Mellitus Type 2

Ahmad Sliem HamdyCorresponding author
Biochemistry and internal Medicine*, Basic oral and medical sciences, College of dentistry, Qassim University, Saudi Arabia
Bioinformatics And Diabetes Cited by 2 doi:10.14302/issn.2374-9431.jbd-13-212

How this research is being cited

The 10 articles above have been cited 86 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Diabetes Mellitus, Experimental, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Bioinformatics And Diabetes (ISSN 2374-9431).

Journal editorial board
Wei Wang · United States Chol Hee Jung · Australia Emile Chimusa · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.