Senescence is the gradual, progressive decline in biological function that accompanies aging, observable both at the level of the whole organism and within individual cells. At the cellular level it describes a state of permanent growth arrest, while at the organismal level it encompasses the cumulative changes that…
Senescence is the gradual, progressive decline in biological function that accompanies aging, observable both at the level of the whole organism and within individual cells. At the cellular level it describes a state of permanent growth arrest, while at the organismal level it encompasses the cumulative changes that increase vulnerability to disease over time. Senescence is closely connected to age-related conditions, including cancer, neurodegenerative disease, and cardiovascular disease. Within Aging Research And Healthcare, senescence is examined through several complementary lines of work represented in the journal's archive. Studies on premature cellular senescence describe how growth arrest can suppress tumor formation, illustrating the protective side of the process. Research on oxidative telomere attrition and nutritional antioxidants addresses molecular drivers of biological aging, while work evaluating SIRT1 and telomerase activity probes the pathways that regulate cellular lifespan. Investigations into frailty and the immune system, and into muscle dysfunction in healthy aging, connect cellular senescence to systemic outcomes that matter for older adults. This page gathers peer-reviewed, open-access research relevant to senescence and the biology of aging.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 35 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Senescence, linking to each citing work.