Research Topic · Peer-Reviewed

Dna Damage Theory of Ageing

The DNA damage theory of aging proposes that the accumulation of damage to cellular DNA over time is a primary driver of the aging process, as cells lose their ability to repair genetic material efficiently with advancing age. Research published in Aging Research And Healthcare has explored connections between this …

Curated from this journal's research 📚 3 peer-reviewed articles cited Cited 19× across the literature 🔖 ISSN 2474-7785 🗓 Reviewed July 2026

Overview

The DNA damage theory of aging proposes that the accumulation of damage to cellular DNA over time is a primary driver of the aging process, as cells lose their ability to repair genetic material efficiently with advancing age. Research published in Aging Research And Healthcare has explored connections between this theory and immune system function, examining how the body's response to foreign substances and cellular damage evolves across the lifespan. One systematic review investigated how immunoglobulin responses to varying levels of xenobiotics—foreign chemical substances—follow trajectories that parallel broader biological changes associated with aging, suggesting a link between environmental exposures, immune function, and age-related decline. Additional work has examined frailty in relation to immune system deterioration, addressing how accumulated cellular and genetic damage may manifest as increased vulnerability in older adults. The journal has also published perspectives questioning whether aging should be viewed primarily through biological frameworks or as a social construct, broadening the discourse beyond purely molecular mechanisms. Understanding DNA damage and its systemic consequences remains relevant for developing interventions that may slow age-related functional decline and improve health outcomes in aging populations.

Research published in this journal

3 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2017

Frailty and the Immune System

Wilson DaisyCorresponding author
Institute of Ageing and Inflammation, University of Birmingham, Edgbaston, Birmingham, UK, B15 2GW
Aging Research And Healthcare Cited by 19 doi:10.14302/issn.2474-7785.jarh-17-1578

How this research is being cited

The 3 articles above have been cited 19 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Dna Damage Theory of Ageing, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Aging Research And Healthcare (ISSN 2474-7785).

Journal editorial board
Anna Aiello · Italy Juan Manuel Carmona Torres · Spain IAN JAMES MARTINS · Australia

This page summarises published research for orientation; it is not medical or professional advice.