Research Topic · Peer-Reviewed

Cancer

Cancer in the context of ageing reflects the strong relationship between advancing age and the development of malignant disease, as the cumulative accumulation of genetic and epigenetic alterations, declining immune surveillance, cellular senescence, and chronic inflammation create a permissive environment for tumou…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 9× across the literature 🔖 ISSN 2474-7785 🗓 Reviewed July 2026

Overview

Cancer in the context of ageing reflects the strong relationship between advancing age and the development of malignant disease, as the cumulative accumulation of genetic and epigenetic alterations, declining immune surveillance, cellular senescence, and chronic inflammation create a permissive environment for tumour initiation and progression. Cancer itself is a group of diseases marked by uncontrolled cell proliferation, evasion of growth control and apoptosis, tissue invasion, and metastasis, and its incidence rises with age across most organ sites, making older adults a growing share of the cancer population. Management in this setting must balance the biology of the tumour with the physiological reserve, comorbidity, and treatment tolerance of older patients, and it spans prevention, screening, diagnosis, and multimodal therapy. Particular themes include the management of multiple neoplasms in the elderly, the organisation and uptake of screening for cervical, breast, colorectal, and thyroid cancer, and the cellular and theoretical basis of tumour resistance and relapse. The peer-reviewed research collected under this topic addresses challenging management of multiple neoplasms in elderly patients, complementary and conventional approaches to prevention, population-based and facility-level screening for several cancers, the molecular regulation of colorectal cancer, and theories of cancer resistance, reflecting the intersection of oncology with ageing and the emphasis on prevention, early detection, and individualised treatment of cancer in older populations.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2016

GR-RNF43 Regulation in Colorectal Cancer

Chan ChristinaCorresponding author
Cell and Molecular Biology Program, Michigan State University, 567 Wilson Road, Rm 2240A, East Lansing, Michigan 48824, USA
Exact topic Proteomics and Genomics Research Cited by 1 doi:10.14302/issn.2326-0793.jpgr-16-941

How this research is being cited

The 12 articles above have been cited 9 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Cancer, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Aging Research And Healthcare (ISSN 2474-7785).

Journal editorial board
Anna Aiello · Italy Juan Manuel Carmona Torres · Spain IAN JAMES MARTINS · Australia

This page summarises published research for orientation; it is not medical or professional advice.